Formaldehyde → 2-Cyano-2-(2-pyridyl)-2-phenyl ethanol

HRID 28267

반응식

HRID 28267 반응식
[C:1]1([CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[CH2:22]=[O:23].[OH-].C([N+](CC)(CC)CC)C1C=CC=CC=1>O>[C:8]([C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:22][OH:23])#[N:9]

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 1049PyridineHCID 74601Benzyltriethylammonium hydroxideHCID 95510alpha-Phenyl-2-pyridineacetonitrile

생성물 1

HCID 233399272-Cyano-2-(2-pyridyl)-2-phenyl ethanol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To an ice cold stirred solution of phenyl-2-pyridyl acetonitrile* (50 g., 0.26 mole) in 350 ml. of pyridine containing a suspension of paraformaldehyde (31 g., 1.0 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 24 hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give a thick oil 58 g, which is identified by nmr.

후처리

  1. additionis added 1 ml
  2. extractionextracted with ether
  3. washThe combined ether extracts are washed with water, saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-431ebc92c4514c90b13adef98fe73719
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225723

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