2-Acetylbenzofuran → 1-(2-Benzofuranyl)-1-(4-methyl-5-thiazolyl)ethanol

HRID 2828

반응식

HRID 2828 반응식
C([Li])CCC.[CH3:6][C:7]1[N:8]=[C:9]([Si](C)(C)C)[S:10][CH:11]=1.[C:16]([C:19]1[O:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=1)(=[O:18])[CH3:17]>C(OCC)C>[O:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=[C:19]1[C:16]([C:11]1[S:10][CH:9]=[N:8][C:7]=1[CH3:6])([OH:18])[CH3:17]

참가 물질

5

반응물 3

HCID 154352-AcetylbenzofuranHCID 116583544-Methyl-2-trimethylsilylthiazoleHCID 178418339Butyllithium

생성물 1

HCID 189363601-(2-Benzofuranyl)-1-(4-methyl-5-thiazolyl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

n-Butyllithium (2.5M solution in hexane, 1 equivalent) was added dropwise to a solution of 4-methyl-2-trimethylsilylthiazole (1 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 2-acetylbenzofuran (1 equivalent) in diethyl ether was added. After 1 hour the mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work up in the normal fashion and column chromatography on silica gel then afforded the title compound.

후처리

  1. waitAfter 1 hour the mixture was allowed
  2. customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate

출처 및 근거

ORD 기록
ord-9c11173c9d7a4647bd65210ad622b55b
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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