Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 2-(6-Chlorohexyloxy)tetrahydro-2H-pyran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 반응물 | 6-Chloro-1-hexanol | HCID 74828 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(6-Chlorohexyloxy)tetrahydro-2H-pyran | HCID 329803 | 86.6% |
반응 단계
To a mixture of 15 g of 6-chlorohexanol, 100 ml of methylenechloride and 0.2 g of p-toluenesulphonic acid were added dropwise 12 g of dihydropyrane in 40 ml of methylenechloride. The reaction mixture was stirred for 15 h at room temperature and then distributed between ether and saturated sodium bicarbonate solution. The ether phase was washed with water, dried over sodium sulphate, filtered and concentrated to dryness. Chromatography of the residue on silica using hexane/ether (3:1) gave 21 g of the product as a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419620B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a770b83f1db64c9a9292a5aa6bd5ee65 |
| 출처 메모 | uspto-grants-2008_09 |