Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-Hydroxy-2-methoxy-estra-1,3,5(10)-triene-17-thione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 반응물 | 2-Methoxyestrone | HCID 440624 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3-Hydroxy-2-methoxy-estra-1,3,5(10)-triene-17-thione | HCID 11594854 | 36% |
반응 단계
A solution of 1.09 g (3.63 mmol) of 3-hydroxy-2-methoxy-estra-1,3,5(10)-trien-17-one in 60 ml of toluene (abs.) was mixed with 3.7 g of Lawesson's reagent, and it was refluxed for four hours. After water was added, it was extracted with dichloromethane (3×), and the combined organic phases were washed with water, dried on sodium sulfate, and concentrated by evaporation in a rotary evaporator. Flash chromatography (n-hexane/ethyl acetate) yielded 412 mg (36%) of the desired product as yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419972B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-2b87ae866ad34a3a88f8e4d53d11a509 |
| 출처 메모 | uspto-grants-2008_09 |