(2-Thienylmethyl)amine → 2-Amino-3-cyano-4-thenylaminoquinoline

HRID 28385

반응식

HRID 28385 반응식
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[CH2:20][NH2:21]>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:21][CH2:20][C:16]2[S:15][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 34005(2-Thienylmethyl)amineHCID 114811212-Amino-3-cyano4-chloroquinoline

생성물 1

HCID 222737202-Amino-3-cyano-4-thenylaminoquinoline수율 49.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

10 g of 2-amino-3-cyano-4-chloroquinoline is heated with 19 g of thienylmethylamine at 115° C. for 4 hours. The reaction mixture is cooled to 25° C. and mixed 6 times with 50 ml of water. The crystals are filtered off, washed 2 times with 50 ml of water and dried. The resulting product is recrystallized from 60 ml of N,N-dimethylformamide, to obtain 6.8 g pale yellow title compound, m.p.: 208-209° C.

후처리

  1. filtrationThe crystals are filtered off
  2. washwashed 2 times with 50 ml of water
  3. customdried
  4. customThe resulting product is recrystallized from 60 ml of N,N-dimethylformamide

출처 및 근거

ORD 기록
ord-5776aca0e38b491ba070be5d1aece8fa
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419977B2

연결된 노트

불러오는 중…