Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | 3'-Amino-4'-hydroxyacetophenone | HCID 13724142 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Acetyl-1,3-benzoxazol-2(3H)-one | HCID 15113571 | — |
반응 단계
7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419974B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-24754a8a8d0d46a5b2104443d26209ef |
| 출처 메모 | uspto-grants-2008_09 |