Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 4-Methylheptanoic acid, (-)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | (6R)-2,6-Dimethylnon-2-ene | HCID 15345839 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-Methylheptanoic acid, (-)- | HCID 13800370 | — |
반응 단계
To (R)-2,6-dimethyl-non-2-ene (20 g, 0.13 mol) in acetone (433 mL) was added a solution of CrO3 (39 g, 0.39 mol) in H2SO4 (33 mL)/H2O (146 mL) over 50 minutes. After 6 hours a further amount of CrO3 (26 g, 0.26 mol) in H2SO4 (22 mL)/H2O (100 mL) was added. After 12 hours the solution was diluted with brine and the solution extracted with ether. The combined organic phases were dried (MgSO4) and concentrated. Flash chromatography (gradient of 6:1 to 2:1 hexane/EtOAc) gave (R)-4-methyl-heptanoic acid as an oil. 12.1 g; 65%. MS, m/z (relative intensity): 143 [M−H, 100%].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419981B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-949975933a6846d19c999aa54016fa41 |
| 출처 메모 | uspto-grants-2008_09 |