Trifluoroacetic acid → (4R)-4,8-Dimethylnonanoic acid

HRID 28447

반응식

HRID 28447 반응식
C([O:5][C:6](=[O:17])[CH2:7][CH2:8][C@H:9]([CH3:16])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][C@H:9]([CH2:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])[CH2:8][CH2:7][C:6]([OH:17])=[O:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71406104tert-butyl (4R)-4,8-dimethylnonanoate

생성물 1

HCID 71351570(4R)-4,8-Dimethylnonanoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(4R)-4,8-dimethyl nonanoic acid t-butyl ester in 25 mL CH2Cl2 at 0° C. was treated with TFA (6 mL). The mixture was allowed to reach ambient temperature and stir overnight. The solvent was removed by rotary evaporation, and the mixture was purified by silica gel chromatography (95/5 hexane/EtOAc) to give 0.962 g (4R)-4,8-dimethyl nonanoic acid. m/z 185 (M−).

후처리

  1. customto reach ambient temperature
  2. customThe solvent was removed by rotary evaporation
  3. customthe mixture was purified by silica gel chromatography (95/5 hexane/EtOAc)

출처 및 근거

ORD 기록
ord-6857fd771a8b44e0b17585c5501f4bf0
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419981B2

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