Methanol → Methyl (2-chlorophenyl)acetate
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]참가 물질
4
실험 절차
To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5%) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).
후처리
- temperaturethe solution was refluxed for 16 hours
- concentrationAfter concentration
- washwashed with sat'd aq. NaHCO3, H2O and brine
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-03a2d924d59c4293b06e1c1ba8bab7f0
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07419983B2
반응 노트
불러오는 중…