Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxybenzaldehyde → 2-Chloro-3-hydroxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxybenzaldehyde | HCID 101 | — |
| 반응물 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Chloro-3-hydroxybenzaldehyde | HCID 593376 | 55% |
반응 단계
To a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL) was added carefully tBuOCl (20 mL, 176 mmol) with stirring. The reaction became a clear solution and strongly exothermic. It was allowed to cool and stirred for 16 hours, resulting in a white precipitate. The solid was filtered, washed with H2O and dried to give 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55%), GCMS (EI) m/z 156, 158 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419983B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-1a18f9f73569446985b955cf53886dc5 |
| 출처 메모 | uspto-grants-2008_09 |