Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonedicarboxylic acid → 8-Benzyl-8-azabicyclo(3.2.1)octan-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonedicarboxylic acid | HCID 68328 | — |
| 반응물 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 반응물 | Amino tropane | HCID 67082042 | — |
| 생성물 | 8-Benzyl-8-azabicyclo(3.2.1)octan-3-one | HCID 119846 | — |
반응 단계
For example, the protected aminotropane intermediate 16 can be prepared by reacting 2,5-dimethoxy tetrahydrofuran 17 with 1,3-acetonedicarboxylic acid 18 to provide 8-benzyl-8-azabicyclo[3.2.1]octan-3-one 19, commonly N-benzyltropanone. N-benzyltropanone is then reacted with a slight excess of di-tert-butyl dicarbonate in the presence of a transition metal catalyst to provide the protected Boc intermediate 20, which is reduced to provide the protected aminotropane intermediate 16.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419989B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-dd6f8a06142f4aa1b15ab253a9404259 |
| 출처 메모 | uspto-grants-2008_09 |