1H-Indazol-6-amine → 6-chloro-N*4*-(1H-indazol-6-yl)-pyrimidine-2,4-diamine

HRID 28530

반응식

HRID 28530 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:10])[CH:8]=2)[CH:3]=[N:2]1.[Cl:11][C:12]1[N:17]=[C:16]([NH2:18])[N:15]=[C:14](NC2C=CC(Cl)=CC=2)[CH:13]=1>>[Cl:11][C:12]1[N:17]=[C:16]([NH2:18])[N:15]=[C:14]([NH:10][C:7]2[CH:8]=[C:9]3[C:4]([CH:3]=[N:2][NH:1]3)=[CH:5][CH:6]=2)[CH:13]=1

참가 물질

3

반응물 2

HCID 814231H-Indazol-6-amineHCID 14842856-chloro-4-N-(4-chlorophenyl)pyrimidine-2,4-diamine

생성물 1

HCID 860043126-chloro-N*4*-(1H-indazol-6-yl)-pyrimidine-2,4-diamine수율 42%

실험 절차

Using 1H-indazol-6-yl-amine in place of 4-chloro-phenylamine in the method described in Example 2 for the synthesis of 6-chloro-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine provided 6-chloro-N*4*-(1H-indazol-6-yl)-pyrimidine-2,4-diamine (42% yield).

출처 및 근거

ORD 기록
ord-9291d5801b7548cbaa3c9701328ebf7b
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

연결된 노트

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