4-Aminobenzonitrile → 4-[2-Amino-6-(5-chloro-2-methyl-phenyl)-pyrimidin-4-ylamino]-benzonitrile

HRID 28545노트

반응식

HRID 28545 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[CH3:15])[N:5]=[C:4]([NH2:16])[N:3]=1.[NH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1>>[NH2:16][C:4]1[N:3]=[C:2]([NH:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[CH3:15])[N:5]=1

참가 물질

3

반응물 2

HCID 133964-AminobenzonitrileHCID 860043474-Chloro-6-(5-chloro-2-methylphenyl)pyrimidin-2-yl-amine

생성물 1

HCID 113136744-[2-Amino-6-(5-chloro-2-methyl-phenyl)-pyrimidin-4-ylamino]-benzonitrile수율 71%

실험 절차

Following the method described in Example 26, 4-chloro-6-(5-chloro-2-methyl-phenyl)-pyrimidin-2-yl-amine and 4-amino-benzonitrile provided the title compound (71% yield). 1H NMR (DMSO-d6) δ 2.36 (s, 3H, CH3), 6.19 (s, 1H, Ar), 6.61 (s, 2H, NH2), 7.32 (d, 1H, J=8.2 Hz, Ar), 7.38 (dd, 1H, J=8.2 Hz, J=2.3 Hz, Ar), 7.43 (d, 1H, J-2.3 Hz, Ar), 7.72 (d, 2H, J=8.8 Hz, Ar), 8.00 (d, 2H, J=8.8 Hz, Ar), 9.73 (s, 1H, NH).

출처 및 근거

ORD 기록
ord-e3df58cf507a49e3bf367b88d613f37f
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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