Water → HCID 178418328, 화합물

HRID 2855

반응식

HRID 2855 반응식
[CH3:1][CH2:2][O:3][C:4]([CH2:6][C:7]([C:9]([F:12])([F:11])[F:10])=[O:8])=[O:5].CC(O[Na])=O.O.[Cl-].[C:20]1([N+:26]#[N:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)C>[C:20]1([NH:26][N:27]=[C:6]([C:7](=[O:8])[C:9]([F:10])([F:11])[F:12])[C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 60992Benzenediazonium chlorideHCID 67793Ethyl 4,4,4-trifluoroacetoacetateHCID 178418247HCID 178418247, 화합물

생성물 1

HCID 178418328HCID 178418328, 화합물수율 60%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

7.3 ml (0.05 mol) of ethyl 3-oxo-4,4,4-trifluoroacetoacetate, 6 g (0.073 mol) of CH3COONa, 20 ml of water, 37.5 ml of ethanol and a solution of 0.05 mol of phenyldiazonium chloride were treated as described in preparation 2. The crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%) obtaining 8.65 g of the title compound. M.p.=78°-80° C.

후처리

  1. customas described in preparation 2
  2. customThe crude product was purified by chromatography on silica gel (hexane/Et2O 0%→25%)

출처 및 근거

ORD 기록
ord-5378909b6f194efbaaaae9d5077f9d43
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

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