1H-Indazol-6-amine → [6-(5-Chloro-2-methyl-phenyl)-2-methyl-pyrimidin-4-yl]-(1H-indazol-6-yl)-amine

참여 물질

반응 단계

Following the method described in Example 38 (alternate method), 4-chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine and 6-aminoindazol provided the title compound (64% yield). 1H NMR (DMSO-d6) δ 2.32 (s, 3H, CH3), 2.57 (s, 3H, CH3), 6.78 (s, 1H, Ar), 7.18 (dd, 1H, J=8.7 Hz, J=1.6 Hz, Ar), 7.36 (d, 1H, J=8.2 Hz, Ar), 7.43 (dd, 1H, J=8.2 Hz, J=2.3 Hz, Ar), 7.49 (d, 1H, J=2.2 Hz, Ar), 7.69 (d, 1H, J=8.6 Hz, Ar), 7.97 (s, 1H, Ar), 8.33 (s, 1H, Ar), 9.75 (s, 1H, NH), 12.89 (s, 1H, NH).

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