Guanidine Hydrochloride → HCID 178431786, 화합물

HRID 28565

반응식

HRID 28565 반응식
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[CH3:6][CH:7]([C:13](OCC)=[O:14])[C:8](OCC)=[O:9].C[O-].[Na+]>C(O)C>[NH2:4][C:3]1[N:5]=[C:8]([OH:9])[C:7]([CH3:6])=[C:13]([OH:14])[N:2]=1

참가 물질

5

반응물 3

HCID 5742Guanidine HydrochlorideHCID 11857Diethyl methylmalonateHCID 10942334Sodium Methoxide

생성물 1

HCID 178431786HCID 178431786, 화합물수율 90%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
65 °C

실험 절차

To a stirred mixture of guanidine hydrochloride (1.91 g, 20.0 mmol) and diethyl methylmalonate (3.48 g, 20.0 mmol) in ethanol (30 ml) was added sodium methoxide (2.7 g, 50.0 mmol, 25% in methanol) dropwise. The cloudy mixture was stirred at 60-70° C. for 16 hours. After evaporation of volatiles under reduced pressure, the residue was treated with 1.0 M hydrochloric acid until pH=2. Filtration and drying provided 2-amino-4,6-dihydroxy-5-methyl-pyrimidine (2.5 g, 90% yield) as a white powder.

후처리

  1. customAfter evaporation of volatiles under reduced pressure
  2. additionthe residue was treated with 1.0 M hydrochloric acid until pH=2
  3. filtrationFiltration
  4. customdrying

출처 및 근거

ORD 기록
ord-1761c4aa3b9744399647612277241c1c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

연결된 노트

불러오는 중…