Bromine → 5-Bromo-4,6-dichloropyrimidin-2-amine

HRID 28567

반응식

HRID 28567 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH2:9])[N:3]=1.C([O-])(=O)C.[Na+].[Br:15]Br>C(O)(=O)C>[NH2:9][C:4]1[N:5]=[C:6]([Cl:8])[C:7]([Br:15])=[C:2]([Cl:1])[N:3]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 655222-Amino-4,6-dichloropyrimidineHCID 517045Sodium Acetate

생성물 1

HCID 6182885-Bromo-4,6-dichloropyrimidin-2-amine수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
60 °C

실험 절차

To a stirred mixture of 4,6-dichloro-pyrimidin-2-yl-amine (2.46 g, 15.0 mmol) and sodium acetate (6.15 g, 75.0 mmol) in acetic acid (150 ml) was added bromine (3.24 g, 20.25 mmol) dropwise. The mixture was then stirred at 60° C. for 2 hours. Volatiles were evaporated under reduced pressure. The residue was stirred with water (500 ml) for 1 hour, filtered, and dried under reduced pressure to provide 2-amino-4,6-dichloro-5-bromo-pyrimidine (3.2 g, 88% yield) as a white solid.

후처리

  1. customVolatiles were evaporated under reduced pressure
  2. stirringThe residue was stirred with water (500 ml) for 1 hour
  3. filtrationfiltered
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-16b556802db94a128af4492aaa101a92
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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