Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Trifluoromethyl)aniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| 반응물 | 4-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine | HCID 86004325 | — |
| 생성물 | 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine | HCID 11281270 | 78% |
반응 단계
Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-trifluoromethyl-phenylamine provided the title compound (78% yield). 1H NMR (DMSO-d6) δ 1.40 (t, 3H, J=6.9 Hz, CH3), 4.15 (q, 2H, J=6.9 Hz, CH2), 6.45 (s, 2H, NH2), 6.84 (s, 1H, Ar), 7.16 (d, 1H, J=8.9 Hz, Ar), 7.43 (dd, 1H, J=8.8 Hz, 2.8 Hz, Ar), 7.61 (d, 2H, J=8.9 Hz, Ar), 7.93 (d, 1H, J=2.8 Hz, Ar), 7.99 (d, 2H, J=8.9 Hz), 9.59 (s, 1H, NH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419984B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-d6a11c9cfb9148bbac935103d80aa7fe |
| 출처 메모 | uspto-grants-2008_09 |