4-Aminobenzonitrile → 4-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzonitrile

HRID 28574

반응식

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[N:5]=[C:4]([NH2:18])[N:3]=1.[NH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1>>[NH2:18][C:4]1[N:3]=[C:2]([NH:19][C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=2)[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[N:5]=1

참가 물질

반응물 2

HCID 133964-Aminobenzonitrile

HCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

생성물 1

HCID 113720034-[2-Amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzonitrile수율 74%

실험 절차

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-amino-benzonitrile provided the title compound (74% yield). 1H NMR (DMSO-d6) δ 1.41 (t, 3H, J=6.9 Hz, CH3), 4.15 (q, 2H, J=7.0 Hz, CH2), 6.53 (s, 2H, NH2), 6.84 (s, 1H, Ar), 7.17 (d, 1H, J-8.9 Hz, Ar), 7.43 (dd, 1H, J=8.8, 2.9 Hz, Ar), 7.71 (d, 2H, J=8.9 Hz, Ar), 7.92 (d, 1H, J=2.9 Hz, Ar), 8.00 (d, 2H, J=8.9 Hz, Ar), 9.70 (s, 1H, NH).

출처 및 근거

ORD 기록: ord-2e96709a5ac74eb2a799f328697bed27
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07419984B2

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