Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → (+/-)-trans-2-Butyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Butyl bromide | HCID 8002 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (+/-)-trans-4a-(3-Methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline hydrochloride | HCID 86752321 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (+/-)-trans-2-Butyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline | HCID 86752323 | 24.9% |
반응 단계
0.71 g (2.55 mmol) of (±)-trans-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline hydrochloride, 0.37 g (2.68 mmol) of butyl bromide, 0.53 g of potassium carbonate and a catalytical amount of potassium iodide in 15 ml of DMF were reacted as described in preparation 20, yielding 0.2 g of the title compound which was used as such in the subsequent step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731322 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-9cef4a5077a74084b0f66091336f0c5e |
| 출처 메모 | uspto-grants-1998_03 |