4-Nitrobenzaldehyde → 5-(4-Nitrophenyl)-1,3-oxazole
반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].S([CH2:22][N+:23]#[C-:24])(C1C=CC(C)=CC=1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CO>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]2[O:9][CH:24]=[N:23][CH:22]=2)=[CH:10][CH:11]=1)([O-:3])=[O:2]참가 물질
5
실험 절차
A mixture of 4-nitro-benzaldehyde (5.0 g, 33.1 mmol), tosylmethyl isocyanide (6.4 g, 33.1 mmol) and potassium carbonate (7.8 g, 82.7 mmol) in methanol (100 ml) was heated under reflux for 30 minutes. After concentrating under reduced pressure, the residue was stirred with water (50 ml). The solid that was filtered to afford 5-(4-nitro-phenyl)-oxazole (5.6 g, 89% yield). 1H NMR (acetone-d6) δ 7.89 (s, 1H, Ar), 8.05 (d, 2H, J=9.3 Hz, Ar), 8.35-8.38 (m, 3H, Ar).
후처리
- temperaturewas heated
- temperatureunder reflux for 30 minutes
- concentrationAfter concentrating under reduced pressure
- filtrationThe solid that was filtered
출처 및 근거
- ORD 기록
- ord-bc34d81bc3ce4fa792e5254ed320c347
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07419984B2
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