Sodium Azide → 2-Azido-1-(4-nitrophenyl)ethanone
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].[N-:14]=[N+:15]=[N-:16].[Na+]>O1CCCC1.C(O)C.O>[N:14]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4])=[N+:15]=[N-:16]참가 물질
6
실험 절차
To a mixture of 2-bromo-1-(4-nitro-phenyl)-ethanone (2.0 g, 8.2 mmol) in tetrahydrofuran (15 ml) and ethanol (15 ml) was added a solution of sodium azide (586 mg, 9.8 mmol) in water (1.5 ml). After stirring for 20 minutes, the mixture was concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (200 ml) and extracted with ethyl acetate (200 ml). The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give crude 2-azido-1-(4-nitrophenyl)-ethanone.
후처리
- concentrationthe mixture was concentrated under reduced pressure
- additionThe residue was treated with saturated aqueous sodium chloride solution (200 ml)
- extractionextracted with ethyl acetate (200 ml)
- dry with materialThe organic layer was dried over magnesium sulfate
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-5782194270b84c77a8c805d693f2ce3c
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07419984B2
반응 노트
불러오는 중…