Sodium Azide → 2-Azido-1-(4-nitrophenyl)ethanone

HRID 28596

반응식

HRID 28596 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].[N-:14]=[N+:15]=[N-:16].[Na+]>O1CCCC1.C(O)C.O>[N:14]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=[O:4])=[N+:15]=[N-:16]

참가 물질

6

반응물 2

HCID 33557Sodium AzideHCID 668402-Bromo-4'-nitroacetophenone

생성물 1

HCID 167492572-Azido-1-(4-nitrophenyl)ethanone

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture of 2-bromo-1-(4-nitro-phenyl)-ethanone (2.0 g, 8.2 mmol) in tetrahydrofuran (15 ml) and ethanol (15 ml) was added a solution of sodium azide (586 mg, 9.8 mmol) in water (1.5 ml). After stirring for 20 minutes, the mixture was concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (200 ml) and extracted with ethyl acetate (200 ml). The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give crude 2-azido-1-(4-nitrophenyl)-ethanone.

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. additionThe residue was treated with saturated aqueous sodium chloride solution (200 ml)
  3. extractionextracted with ethyl acetate (200 ml)
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5782194270b84c77a8c805d693f2ce3c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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