4-Chloroaniline → HCID 11406630, 화합물

HRID 28600

반응식

HRID 28600 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:16])=[C:6]([C:8]2[CH:13]=[C:12](Cl)[N:11]=[C:10]([NH2:15])[N:9]=2)[CH:7]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:16])=[C:6]([C:8]2[N:9]=[C:10]([NH2:15])[N:11]=[C:12]([NH:24][C:21]3[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=3)[CH:13]=2)[CH:7]=1

참가 물질

3

반응물 2

HCID 78124-ChloroanilineHCID 860043412-Amino-4-chloro-6-(2-methyl-5-bromo-phenyl)-pyrimidine

생성물 1

HCID 11406630HCID 11406630, 화합물수율 76%

실험 절차

Following the method described in Example 26, 4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound (76% yield). 1H NMR (DMSO-d6) δ 2.35 (s, 3H, CH3), 6.39 (s, 1H, Ar), 7.40 (d, 1H, J=8.4 Hz, Ar), 7.47 (d, 2H, J=8.5 Hz, Ar), 7.70-7.71 (m, 2H, Ar), 7.84-7.89 (m, 2H, Ar), 10.95 (br s, 1H, NH).

출처 및 근거

ORD 기록
ord-b3578ec648eb4b5bb69ed4b40ddacccf
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

연결된 노트

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