2-Amino-4,6-dichloropyrimidine → 2-Pyrimidinamine,4-(3-bromophenyl)-6-chloro-

HRID 28625노트

반응식

HRID 28625 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12](Cl)[CH:11]=[CH:10][C:9]=2OCC)[N:5]=[C:4]([NH2:18])[N:3]=1.[Br:19]C1C=C(B(O)O)C=CC=1.NC1N=C(Cl)C=C(Cl)N=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([Br:19])[CH:13]=2)[N:5]=[C:4]([NH2:18])[N:3]=1

참가 물질

4

반응물 3

HCID 655222-Amino-4,6-dichloropyrimidineHCID 2734318(3-Bromophenyl)boronic acidHCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

생성물 1

HCID 587333892-Pyrimidinamine,4-(3-bromophenyl)-6-chloro-

실험 절차

4-Chloro-6-(3-bromo-phenyl)-pyrimidin-2-ylamine was prepared according to the method described for 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine (Example 53) using 3-bromophenyl boronic acid and 2-amino-4,6-dichloropyrimidine.

출처 및 근거

ORD 기록
ord-0dbb5c3a2fc24532802ca8f58207034a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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