Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine → 4-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine | HCID 86004374 | — |
| 반응물 | 2-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol | HCID 136080012 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | 4-[5-Bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine | HCID 86004380 | 42% |
반응 단계
Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-methoxy-ethanol provided 4-[5-bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine (42% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419984B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-999ac6a17c854f6d814498b7c611ec8a |
| 출처 메모 | uspto-grants-2008_09 |