반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]1[CH:21]=[C:20](Cl)[N:19]=[C:18]([NH2:23])[N:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][OH:33])=[CH:27][CH:26]=1>>[NH2:23][C:18]1[N:19]=[C:20]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][OH:33])=[CH:27][CH:26]=2)[CH:21]=[C:16]([C:10]2[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=2[O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:17]=1참가 물질
3
실험 절차
Following the method described in Example 72, 4-(2-benzyloxy-5-chloro-phenyl)-6-chloro-pyrimidin-2-ylamine and 2-(4-amino-phenyl)-ethanol provided the title compound (71% yield). 1H NMR (CD3OD) δ 2.85 (t, 2H, J=6.9 Hz, CH2), 3.78 (t, 2H, J=6.9 Hz, CH2), 5.27 (s, 2H, CH2), 6.42 (s, 1H, Ar), 7.28-7.30 (m, 2H, Ar), 7.32-7.36 (m, 2H, Ar), 7.39 (d, 4H, J=6.3 Hz, Ar), 7.58 (d, 2H, J=8.4 Hz, Ar), 7.68-7.70 (m, 2H, Ar).
출처 및 근거
- ORD 기록
- ord-fb22753ac883437a9a37278ccfcc4fec
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07419984B2
연결된 노트
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