Cyclohexane, (bromomethyl)- → 4-Chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine

HRID 28652노트

반응식

HRID 28652 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[OH:15])[CH:5]=[C:4]([Cl:16])[N:3]=1.Br[CH2:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[Cl:16][C:4]1[CH:5]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2[O:15][CH2:18][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:7]=[C:2]([NH2:1])[N:3]=1

참가 물질

3

반응물 2

HCID 137636Cyclohexane, (bromomethyl)-HCID 1363418892-(2-Amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol

생성물 1

HCID 860043894-Chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine수율 20%

실험 절차

Following the method described in Example 72, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-chloro-phenol and bromomethyl-cyclohexane provided 4-chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-ylamine (20% yield).

출처 및 근거

ORD 기록
ord-778cf8719f8249e19044b040f9b929ea
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419984B2

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