Sulfuric Acid → HCID 20110268, 화합물

HRID 28774노트

반응식

HRID 28774 반응식
C[CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])[C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[C:22](=O)([O-])[O-].[Na+].[Na+]>CO>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:3]1([C:7]([O:9][CH3:22])=[O:8])[CH2:4][CH2:5][CH2:6][CH2:2]1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 69250408Methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid

생성물 1

HCID 20110268HCID 20110268, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid (5.0 g, 24.01 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

후처리

  1. temperatureThe mixture was refluxed for overnight
  2. customThe solvent was evaporated
  3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
  4. washwashed with brine (3×10 mL)
  5. dry with materialdried over MgSO4
  6. customThe crude product was used for the next reaction without further purification

출처 및 근거

ORD 기록
ord-04cf99ab5d9c48e289c766d5829a0809
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419999B2

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