1-(2-[(3S)-3-(methylamino)piperidin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride → HCID 86600411, 화합물
반응식
[ClH:1].Cl.CN[C@H]1CCCN([CH2:11][CH:12]([C:24]2([OH:30])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)C1.OC1(C(C2C=CC=C(OC(F)(F)F)C=2)C([N:41]2[CH2:46][CH2:45][CH2:44][C@H:43]([NH:47][C:48](=O)OC(C)(C)C)[CH2:42]2)=O)CCCCC1>>[ClH:1].[ClH:1].[CH3:48][NH:47][C@H:43]1[CH2:44][CH2:45][CH2:46][N:41]([CH:25]2[CH2:26][CH2:27][CH2:28][CH2:29][C:24]2([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:22])([F:21])[F:23])[CH:14]=2)[CH3:11])[OH:30])[CH2:42]1참가 물질
3
실험 절차
In an analogous manner to Example 13, step 2, 1-(2-[(3S)-3-(methylamino)piperidin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl ((3S)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethoxy)phenyl]acetyl}piperidin-3-yl)carbamate. MS m/z 401; HRMS: calcd for C21H31F3N2O2+H, 401.24159; found (ESI, [M+H]+), 401.2419.
출처 및 근거
- ORD 기록
- ord-8f79359485e2423e9320706a4526c89b
- 출처 데이터셋
- uspto-grants-2008_09
- DOI