Water → 2-(7-Methoxy-1-naphthyl)ethanol

HRID 2884

반응식

HRID 2884 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[C:16]2[CH2:19][C:20](OC)=[O:21])=[CH:11][CH:10]=1.O.[H-]>CCOCC>[CH3:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[C:16]2[CH2:19][CH2:20][OH:21])=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 166653HydrideHCID 15453078Methyl (7-methoxy-1-naphthyl)acetateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 135700652-(7-Methoxy-1-naphthyl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

3.34 g of lithium aluminum hydride are placed in a 250-cm3 flask, and ether is added gently with stirring. Using a dropping funnel, 5 g of methyl (7-methoxy-1-naphthyl)acetate previously dissolved in 50 cm3 of ether are added slowly. The reaction medium is left stirring for 30 minutes. It is poured very slowly into a mixture of water and ice so as to hydrolyze the excess unreacted hydride. The reaction medium is filtered. The aqueous phase is extracted with 3 times 50 cm3 of ether, and the ether phases are dried over magnesium sulfate and evaporated. The white solid obtained is recrystallized.

후처리

  1. additionare added slowly
  2. waitThe reaction medium is left
  3. stirringstirring for 30 minutes
  4. filtrationThe reaction medium is filtered
  5. extractionThe aqueous phase is extracted with 3 times 50 cm3 of ether
  6. dry with materialthe ether phases are dried over magnesium sulfate
  7. customevaporated
  8. customThe white solid obtained
  9. customis recrystallized

출처 및 근거

ORD 기록
ord-0c37bb1656a64973bff4ef3e79448c12
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731352

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