참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | (4-Boc-Aminophenyl)Boronic Acid | HCID 3613184 | — |
| 반응물 | Barium hydroxide | HCID 6093286 | — |
| 반응물 | 4-(3-Bromothiophen-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine | HCID 68997816 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 1,1-dimethylethyl {4-[2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-3-thienyl]phenyl}carbamate | HCID 86617391 | 40% |
반응 단계
To a solution of 4-(3-bromo-2-thienyl)-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine (5.3 mmol) in 40 mL of 1,2-dimethoxyethane was added 4-(N-Boc-amino)phenyl boronic acid (13.8 mmol), tetrakis(triphenylphosphine)palladium(0), (0.17 mmol), water (16 mL) and barium hydroxide (21.2 mmol). The reaction was heated at 80° C. for 36 h. The 1,2-dimethoxyethane was evaporated and the residue taken up in ethyl acetate and washed with water (50 mL). The crude product was purified by silica gel chromatography (0-50% ethyl acetate/hexanes) to give the title compound (40%). ESMS [M+H]+: 392.2
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07419988B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-86e5bffe89514f43856b684c8f1e506d |
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| 출처 메모 | uspto-grants-2008_09 |
|---|
