Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Guanidine → N-diaminomethylene-2-methyl-4-ethenyl-5-methylsulfonyl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Guanidine | HCID 3520 | — |
| 반응물 | Methyl 4-bromo-5-methanesulfonyl-2-methylbenzoate | HCID 10590825 | — |
| 반응물 | N-diaminomethylene-2-methyl-4-ethynyl-5-methylsulfonylbenzamide | HCID 19688115 | — |
| 반응물 | Methyl 2-methyl-4-ethynyl-5-methylsulfonyl-benzoate | HCID 19688249 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Calcium Palladium Carbonate | HCID 12000666 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-diaminomethylene-2-methyl-4-ethenyl-5-methylsulfonyl-benzamide | HCID 19688146 | — |
반응 단계
6.0 g of N-diaminomethylene-2-methyl-4-ethynyl-5-methylsulfonylbenzamide, m.p. 223°-226° [obtainable by reaction of methyl 2-methyl-4-bromo-5-methylsulfonyl-benzoate with Li acetylide to give methyl 2-methyl-4-ethynyl-5-methylsulfonyl-benzoate and subsequent reaction with guanidine] are dissolved in 300 ml of DMF and hydrogenated in the presence of 450 mg of Pd-CaCO3 (Lindlar catalyst) for 15 minutes in a stream of hydrogen (p=1 bar). Customary working up gives N-diaminomethylene-2-methyl-4-ethenyl-5-methylsulfonyl-benzamide).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731351 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-b9a7eb44685f468d8f6ff10d7448f0ce |
| 출처 메모 | uspto-grants-1998_03 |