1-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazine → [4-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

반응식

[CH3:18][S:19](=[O:20])(=[O:21])[c:22]1[cH:23][cH:24][c:25](-[c:31]2[s:32][cH:33][cH:34][n:35]2)[c:26]([C:27](=[O:28])[OH:29])[cH:30]1.[F:1][c:2]1[cH:3][c:4]([N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[cH:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]>>[F:1][c:2]1[cH:3][c:4]([N:12]2[CH2:13][CH2:14][N:15]([C:27]([c:26]3[c:25](-[c:31]4[s:32][cH:33][cH:34][n:35]4)[cH:24][cH:23][c:22]([S:19]([CH3:18])(=[O:20])=[O:21])[cH:30]3)=[O:28])[CH2:16][CH2:17]2)[cH:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]

참가 물질

반응물 2

HCID 597935951-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazine

HCID 598537385-Methanesulfonyl-2-thiazol-2-yl-benzoic acid

생성물 1

HCID 59853749[4-(3-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

출처 및 근거

ORD 기록: ord-724af3bb0f2644a19541ed5787e96355
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

반응 노트

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