C([O-])([O-])=O.[K+].[K+].Br[CH2:8][CH2:9][CH:10]=[CH2:11].N[C@H:13](C(O)=O)[CH2:14][C:15]1[CH:24]=[C:23]2[C:18](C=CC=C2)=[CH:17][CH:16]=1.C[N:29](C=O)C>CCOCC>[CH2:8]([NH:29][C@H:14]([C:15]1[CH:24]=[CH:23][CH:18]=[CH:17][CH:16]=1)[CH3:13])[CH2:9][CH:10]=[CH2:11]To a solution of S-(−)-1-phenyl ethylamine (15.75 g, 130 mmol) in 150 mL of DMF at 0° C. is added K2CO3 (53.9 g, 390 mmol) in small portions. After stirring at 0° C. for 10 min, 4-bromobutene (13.5 g, 100 mmol) is added dropwise and followed by Nal (58.5 g, 390 mmol) in small portions. The reaction mixture, a white suspension, is heated to 95° C. and stirred overnight/16 hrs. The solution is cooled to RT and diluted with 200 mL of ether, and washed with 3×100 ml of water. The organic layer is dried over Na2SO4 and concentrated. The crude product is purified by distillation (65˜70° C. under high vacuum) to yield a colorless liquid(13.5 g, 76.7%). (NMR and MS data confirmed, U-4117-28-23).
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