참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,4-Dichlorobenzene | HCID 4685 | — |
| 반응물 | 3-Methylbenzoyl chloride | HCID 74375 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (2,5-Dichlorophenyl)(3-methylphenyl)methanone | HCID 18704036 | 53% |
반응 단계
A mixture of m-toluoyl chloride (22 g, 0.17 mol) and 1,4-dichlorobenzene (120 g, 0.82 mol) was heated to 100° C. in a flask. Aluminum chloride (60 g, 0.45 mol) was added in one portion. Hydrogen chloride started to evolve from the solution. The mixture was heated to 170° C. in 30 min. and stirred at this temperature for 3 hours. The resulting brownish solution was cooled to about 80° C. and poured onto ice. Ether (50 ml) was added. The organic layer was separated and distilled under vacuum after the removal of ether. The residue from distillation was recrystallized twice from hexane to give 20 g of white crystals (53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05731400 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-4ed142657f3d431e82ca203fc86540a6 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
