참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 4-Hydroxymethyl-3-methylbenzofuran-2-carboxylic acid ethyl ester | HCID 68711892 | — |
| 촉매 | Silver(II) oxide | HCID 92152 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Ethyl 4-(methoxymethyl)-3-methyl-1-benzofuran-2-carboxylate | HCID 68715936 | 93.8% |
반응 단계
To a solution of 0.19 g (0.81 mmole) of ethyl 4-(hydroxymethyl)-3-methyl-1-benzofuran-2-carboxylate (Example 92, Step 2) in 2 mL of chloroform was added silver (II) oxide (0.34 g, 1.46 mmol, 1.8 eq) and 2 mL of iodomethane and the mixture was heated in sealed tube at ˜55° C. for 4.5 days. The reaction was filtered and concentrated in vacuo to provide 0.20 g of ethyl 4-(methoxymethyl)-3-methyl-1-benzofuran-2-carboxylate. Yield: ˜93.8% m.p. 45-47° C.; MS: 249.1(M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07420001B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-faa43fcc2f5947b3afc920a756a3a1bb |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
