2-Bromopropane → HCID 68716041, 화합물

HRID 29338노트

반응식

HRID 29338 반응식
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[C:8]=2[CH:9]=1)=[O:4].Br[CH:16]([CH3:18])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:16]([O:14][C:10]1[C:8]2[CH:9]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[O:6][C:7]=2[CH:13]=[CH:12][CH:11]=1)([CH3:18])[CH3:17]

참가 물질

5

반응물 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 14494065Methyl 4-hydroxybenzofuran-2-carboxylate

생성물 1

HCID 68716041HCID 68716041, 화합물수율 100%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 0.41 g (2.13 mmol) of 4-hydroxy-2-benzofurancarboxylic acid methyl ester in 7 mL of DMF was added 0.80 mL (8.54 mmol) of 2-bromopropane and 1.18 g (8.54 mmol) of potassium carbonate. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo, and the residue was extracted with ethyl acetate. The organic layer washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 0.49 g of methyl 4-isopropoxy-1-benzofuran-2-carboxylate. Yield ˜100%; m.p. 43-45° C.; MS: 235.1 (M+H)+.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe organic layer washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-15c5f1d5dfe849a5a6c5355f7b711ebf
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

반응 노트

불러오는 중…