Potassium Carbonate → HCID 68712423, 화합물

HRID 29348노트

반응식

HRID 29348 반응식
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2].I[CH2:18][CH2:19][CH3:20].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:18][CH2:19][CH3:20])[C:9]=2[C:10]=1[CH3:11])=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 748649Ethyl 4-hydroxy-3-methyl-1-benzofuran-2-carboxylate

생성물 1

HCID 68712423HCID 68712423, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (200 mg) was mixed with iodopropane (0.5 mL), K2CO3 (200 mg) and 2 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent gave the crude product, which was purified by column chromatography to give 176 mg of 3-methyl-4-propoxy-benzofuran-2-carboxylic acid ethyl ester as white solid.

후처리

  1. washThe mixture was washed with brine
  2. extractionextracted with ethyl acetate
  3. washThe combined ethyl acetate layers were washed with brine
  4. customRemoval of the solvent
  5. customgave the crude product, which
  6. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-0ff30e0359654816a8646639116c4c8d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420001B2

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