Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromoacetonitrile → 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-oxo-3-thiazolidineacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromoacetonitrile | HCID 11534 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-(3,5-Bis(tert-butyl)-4-hydroxyphenyl)methylene-4-thiazolidinone | HCID 130003 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-oxo-3-thiazolidineacetonitrile | HCID 54120060 | 40.7% |
반응 단계
7.03 g of 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-thiazolidinone and 2.64 g of bromoacetonitrile were reacted in the presence of 0.97 g of 60% sodium hydride in mineral oil and 330 ml of tetrahydrofuran. Work-up of the reaction mixture provided 3.21 g of the desired title product, m.p. 186°-188° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731336 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-20eb6cc14ae4481ca9a1fde22cf62941 |
| 출처 메모 | uspto-grants-1998_03 |