Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2-Chloromethyl-3-methyl-benzofuran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 3-Methyl-2-benzofuranmethanol | HCID 10241108 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Chloromethyl-3-methyl-benzofuran | HCID 10261721 | — |
반응 단계
To a solution of (3-methyl-benzofuran-2-yl)-methanol (1.12 g, 6.9 mmol) in 12 mL of dichloromethane was added 2.8 mL of thionyl chloride. The color of the reaction turned from pink initially to light yellow. After 2 h the reaction was worked up and 2-chloromethyl-3-methyl-benzofuran was obtained in quantitative yield. 1H NMR (400 MHz, CDCl3) δ ppm 2.3 (s, 3 H) 4.7 (s, 2 H) 7.2 (m, 1 H) 7.3 (m, 1 H) 7.5 (m, 1 H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07420001B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a66555378cb34fb9a2f6f0a343230fb8 |
| 출처 메모 | uspto-grants-2008_09 |