Dichloromethane → 2-[1-Methyl-4-phenyl-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-imidazol-5-yl][1,3]thiazolo[5,4-d]pyrimidin-7-amine

HRID 295077노트

반응식

[Cl:43][CH2:44][Cl:45].[F:36][C:37]([F:38])([F:39])[C:40]([OH:41])=[O:42].[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9](-[c:11]1[c:12](-[c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[n:13][c:14]([C:17]3=[CH:22][CH2:21][N:20]([C:23]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:29])[CH2:19][CH2:18]3)[n:15]1[CH3:16])[n:10]2>>[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9](-[c:11]1[c:12](-[c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[n:13][c:14]([C:17]3=[CH:22][CH2:21][NH:20][CH2:19][CH2:18]3)[n:15]1[CH3:16])[n:10]2

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 69553700tert-Butyl 4-[5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazol-2-yl]-3,6-dihydropyridine-1(2H)-carboxylate

생성물 1

HCID 104754582-[1-Methyl-4-phenyl-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-imidazol-5-yl][1,3]thiazolo[5,4-d]pyrimidin-7-amine

출처 및 근거

ORD 기록: ord-c8c026b046be49f1b23f784dce63716e
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

반응 노트

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