6-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one → tert-Butyl 4-{4-[3-(2,5-difluorophenoxy)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

반응식

[Cl:34][CH2:35][c:36]1[cH:37][cH:38][c:39]2[c:40]([cH:51]1)[N:41]([CH2:46][CH2:47][CH2:48][O:49][CH3:50])[C:42](=[O:45])[CH2:43][O:44]2.[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([OH:28])[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:29][c:30]([F:33])[cH:31][cH:32]1>>[F:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:28][CH2:35][c:36]4[cH:37][cH:38][c:39]5[c:40]([cH:51]4)[N:41]([CH2:46][CH2:47][CH2:48][O:49][CH3:50])[C:42](=[O:45])[CH2:43][O:44]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:29][c:30]([F:33])[cH:31][cH:32]1