Formaldehyde → N-tert-Butyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

HRID 29722

반응식

HRID 29722 반응식
[C:1]([NH:5][CH2:6][Si:7]([CH3:10])([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2].[CH2:11]=O.CO.[C:15](=[O:18])([O-])[O-].[K+].[K+]>O>[C:1]([N:5]([CH2:11][O:18][CH3:15])[CH2:6][Si:7]([CH3:10])([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 887MethanolHCID 11430Potassium CarbonateHCID 425246N-tert-Butyl-N-(trimethylsilylmethyl)amine

생성물 1

HCID 22228418N-tert-Butyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-tert-Butyl-N-(trimethylsilylmethyl)amine 77 (8.47 g, 53.1 mmol) was added dropwise, over approximately 30 min, via a pressure equalizing addition funnel to a stirred solution of aqueous formaldehyde (5.98 mL of a 37 wt. % solution in water, 79.7 mmol) at 0° C. After 45 min, methanol (6.45 mL, 159.3 mmol) was added and the resulting solution was saturated with potassium carbonate. After stirring vigorously for approximately 5 h, the aqueous phase was removed. The organic phase was saturated with potassium carbonate and stirred overnight. The reaction mixture was poured into water and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4) and the volatiles evaporated in vacuo. Distillation (high vacuum; ˜70° C.) of the residual liquid afforded the title compound 78 as a colorless liquid.

후처리

  1. customat 0° C
  2. customthe aqueous phase was removed
  3. stirringstirred overnight
  4. additionThe reaction mixture was poured into water
  5. extractionextracted three times with diethyl ether
  6. washThe combined organic extracts were washed with brine
  7. dry with materialdried (MgSO4)
  8. customthe volatiles evaporated in vacuo
  9. distillationDistillation (high vacuum; ˜70° C.) of the residual liquid

출처 및 근거

ORD 기록
ord-4be3b5d08bb7443aa7e8a341d9733152
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419990B2

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