Ethanol → N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

HRID 29732노트

반응식

HRID 29732 반응식
[Cl-:1].[NH4+].O.C(O)C.[N+:7]([C:10]1[CH:34]=[CH:33][C:13]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([O-])=O>CN1C(=O)CCC1.[Zn]>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[NH2:30][C:27]1[CH:26]=[CH:25][C:24]([NH:23][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:13]3[CH:33]=[CH:34][C:10]([NH2:7])=[CH:11][CH:12]=3)=[CH:17][CH:18]=2)=[CH:29][CH:28]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 236567624-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline

생성물 1

HCID 69252903N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

The mixture of powdered zinc (22.2 g), ammonium chloride (2.5 g), water (4 ml) and absolute ethanol (20 ml) were brought to reflux with the oil bath. The 4-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline (3.4 g) was dissolved in 20 ml of NMP and introduced dropwise until there was decoloration of the reaction medium, while at the same time the reflux was maintained.

후처리

  1. temperatureto reflux with the oil bath
  2. additionintroduced dropwise until there
  3. temperaturewhile at the same time the reflux was maintained

출처 및 근거

ORD 기록
ord-210702c204ef409592efd42d6c840278
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07422609B2

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