Acetic Acid → 7-[3-(1H-Pyrrol-1-ylmethyl)phenoxy]-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide

HRID 29772노트

반응식

HRID 29772 반응식
Cl.[O:2]=[S:3]1(=[O:25])[C:8]2[CH:9]=[C:10]([O:13][C:14]3[CH:15]=[C:16]([CH2:20][NH2:21])[CH:17]=[CH:18][CH:19]=3)[CH:11]=[CH:12][C:7]=2[N:6]2[CH2:22][CH2:23][CH2:24][CH:5]2[NH:4]1.CO[CH:28]1[CH2:32][CH2:31][CH:30](OC)O1.O.CC(O)=O>C(Cl)CCl>[N:21]1([CH2:20][C:16]2[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=2)[O:13][C:10]2[CH:11]=[CH:12][C:7]3[N:6]4[CH2:22][CH2:23][CH2:24][CH:5]4[NH:4][S:3](=[O:2])(=[O:25])[C:8]=3[CH:9]=2)[CH:28]=[CH:32][CH:31]=[CH:30]1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 962WaterHCID 790982,5-DimethoxytetrahydrofuranHCID 69197863HCID 69197863, 화합물

생성물 1

HCID 691987587-[3-(1H-Pyrrol-1-ylmethyl)phenoxy]-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

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온도
80 °C

실험 절차

200 mg (0.58 mmol) of the product obtained in Example 1, in the form of the free amine, and 105 μl (0.81 mmol) of 2,5-dimethoxytetrahydrofuran are added to a two-phase mixture of 2.5 ml of water, 0.95 ml of AcOH and 2.85 ml of dichloro-1,2-ethane. The mixture is stirred at 80° C. for 2 hours, allowed to return to ambient temperature and extracted with CH2Cl2. The organic phase is washed with saturated aqueous NaCl solution and dried over MgSO4. The expected product is purified by chromatography on a silica column (CH2Cl2/heptane 75/25).

후처리

  1. customto return to ambient temperature
  2. extractionextracted with CH2Cl2
  3. washThe organic phase is washed with saturated aqueous NaCl solution
  4. dry with materialdried over MgSO4
  5. customThe expected product is purified by chromatography on a silica column (CH2Cl2/heptane 75/25)

출처 및 근거

ORD 기록
ord-193c00d47d504ab2bdf9af6b0c39ec60
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423034B2

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