Benzyl Bromide → N-Benzylnormechlorethamine

HRID 29862

반응식

HRID 29862 반응식
Cl.[Cl:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][Cl:8].[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>CN(C=O)C>[Cl:2][CH2:3][CH2:4][N:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH2:7][Cl:8]

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 522769Bis(2-chloroethyl)amine hydrochloride

생성물 1

HCID 5928N-Benzylnormechlorethamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An ice bath is used to cool a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF and then 120 ml of triethylamine are added dropwise and the mixture is left with stirring at AT overnight. The reaction mixture is concentrated under vacuum, the residue is taken up in water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.

후처리

  1. customAn ice bath is used
  2. temperatureto cool
  3. waitthe mixture is left
  4. concentrationThe reaction mixture is concentrated under vacuum
  5. extractionextracted 3 times with ether
  6. dry with materialthe organic phases are dried over Na2SO4
  7. customthe solvent is evaporated under vacuum

출처 및 근거

ORD 기록
ord-a9bfd6e512c14c1f87f97806cb513292
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423039B2

연결된 노트

불러오는 중…