Benzyl Bromide → N-Benzylnormechlorethamine
반응식
Cl.[Cl:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][Cl:8].[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>CN(C=O)C>[Cl:2][CH2:3][CH2:4][N:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH2:7][Cl:8]참가 물질
5
실험 절차
An ice bath is used to cool a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF and then 120 ml of triethylamine are added dropwise and the mixture is left with stirring at AT overnight. The reaction mixture is concentrated under vacuum, the residue is taken up in water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.
후처리
- customAn ice bath is used
- temperatureto cool
- waitthe mixture is left
- concentrationThe reaction mixture is concentrated under vacuum
- extractionextracted 3 times with ether
- dry with materialthe organic phases are dried over Na2SO4
- customthe solvent is evaporated under vacuum
출처 및 근거
- ORD 기록
- ord-a9bfd6e512c14c1f87f97806cb513292
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07423039B2
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