Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-[3-(4-Fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 69222399 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride | HCID 86607288 | 96% |
반응 단계
4-[3-(4-fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (15 g, 0.036 mol) was dissolved in 4 N HCl in dioxane (160 mL) and stirred overnight at room temperature. The volume of the reaction was reduced to remove most of the dioxane and the residue was filtered to afford piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride (11.7 g, 96%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423043B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-df0ca034e999438b96d35e807db3cd9d |
| 출처 메모 | uspto-grants-2008_09 |