Hydrochloric Acid → Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride

HRID 29883

반응식

HRID 29883 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:30])[NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>O1CCOCC1>[ClH:31].[F:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:18]2[CH:17]=[C:16]([NH:15][C:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:30])[CH:21]=[CH:20][CH:19]=2)=[CH:24][CH:25]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 692223994-[3-(4-Fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 86607288Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride수율 96%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-[3-(4-fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (15 g, 0.036 mol) was dissolved in 4 N HCl in dioxane (160 mL) and stirred overnight at room temperature. The volume of the reaction was reduced to remove most of the dioxane and the residue was filtered to afford piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride (11.7 g, 96%) as a white solid.

후처리

  1. customto remove most of the dioxane
  2. filtrationthe residue was filtered

출처 및 근거

ORD 기록
ord-df0ca034e999438b96d35e807db3cd9d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423043B2

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