4-Fluorobenzyl bromide → 4-[(4-Fluorobenzyl)oxy]-2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 29899

반응식

HRID 29899 반응식
[C:1]1([C:7]2[N:12]=[C:11]([OH:13])[C:10]3[CH2:14][CH2:15][CH2:16][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Br)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH2:22][O:13][C:11]2[C:10]3[CH2:14][CH2:15][CH2:16][C:9]=3[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:12]=2)=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 680214-Fluorobenzyl bromideHCID 178517455HCID 178517455, 화합물2회

생성물 1

HCID 117235234-[(4-Fluorobenzyl)oxy]-2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

실험 절차

The title compound was prepared from 2-phenyl-6,7-dihydro-5H-cyclopentapyrimidin-4-ol (which was obtained in Intermediate 5) and 4-fluorobenzyl bromide according to Method A; LC retention time 3.26 min; MS: m/z (ESI) 321 (M+H).

출처 및 근거

ORD 기록
ord-427b996b8384497b91c8121c533f3034
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423044B2

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