Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Bromomethyl)-4-(trifluoromethyl)benzene → 4-Isopropyl-2-(3-nitrophenyl)-6-{[4-(trifluoromethyl)benzyl]oxy} pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| 반응물 | HCID 178439455 | HCID 178439455 | — |
| 생성물 | 4-Isopropyl-2-(3-nitrophenyl)-6-{[4-(trifluoromethyl)benzyl]oxy} pyrimidine | HCID 10070573 | — |
반응 단계
The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and 4-(trifluoromethyl)benzyl bromide according to Method A; 1H NMR (DMSO-d6, 300 MHz) δ 1.30 (d, J=6.8 Hz, 6H), 3.00-3.10 (m, 1H), 5.69 (s, 2H), 6.95 (s, 1H), 7.75-7.85 (m, 4H), 7.84 (t, J=8.1 Hz, 1H), 8.38 (t, J=8.1 Hz, 1H), 8.80 (d, J=7.8 Hz, 1H), 9.08 (s, 1H); LC retention 4.18 min; MS: m/z (ESI) 418 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423044B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-fd1604433a7142f08720bc7c6537dbf9 |
| 출처 메모 | uspto-grants-2008_09 |